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Papers to Watch

Y. Zhou et al., "The mammalian Golgi regulates numb signaling in asymmetric cell division by releasing ACBD3 during mitosis," Cell, 129:163-78, Apr. 6, 2007. This excellent paper reports a novel means of coupling cell-cycle progression with cell fate decisions. The authors show that the fragmentation of the Golgi complex, which precedes mitosis of neural progenitor cells, releases a Numb binding protein, thereby modulating cell fate decisions fol

The Scientist Staff

Y. Zhou et al., "The mammalian Golgi regulates numb signaling in asymmetric cell division by releasing ACBD3 during mitosis," Cell, 129:163-78, Apr. 6, 2007.

This excellent paper reports a novel means of coupling cell-cycle progression with cell fate decisions. The authors show that the fragmentation of the Golgi complex, which precedes mitosis of neural progenitor cells, releases a Numb binding protein, thereby modulating cell fate decisions following asymmetric cell division.

-Mark Bothwell
University of Washington, USA

C.A. Miller et al., "Covalent modification of DNA regulates memory formation," Neuron, 53:857-69, Mar. 15, 2007.

During hippocampal memory formation, transient DNA methylation regulates the expression of two genes, the memory suppressor phosphatase 1 and the plasticity gene reelin. Prevention of this DNA methylation impairs memory formation.

-Karl-Peter Giese
King's College London, United Kingdom

N.B. Sutter, et al., "A single IGF1 allele is a major determinant of small size in dogs,"...

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