Papers to watch

C.A. Feillet et al., "Lack of food anticipation in Per2 mutant mice," Curr Biol, 16:2016-22, Oct. 24, 2006. The two period genes, Per1 and Per2, are integral parts of biological rhythm generation in the body's master clock, housed in the hypothalamic suprachiasmatic nuclei. The authors show now that the absence of Per2 expression abolishes the centrally regulated anticipation of meal times without interfering with the entrainment of peripheral clocks by nu

The Scientist Staff
Feb 28, 2007

C.A. Feillet et al., "Lack of food anticipation in Per2 mutant mice," Curr Biol, 16:2016-22, Oct. 24, 2006.

The two period genes, Per1 and Per2, are integral parts of biological rhythm generation in the body's master clock, housed in the hypothalamic suprachiasmatic nuclei. The authors show now that the absence of Per2 expression abolishes the centrally regulated anticipation of meal times without interfering with the entrainment of peripheral clocks by nutritional cues.

Ralf Jockers
Cochin Institute, INSERM, France

P.J. Turnbaugh et al., "An obesity-associated gut microbiome with increased capacity for energy harvest," Nature, 444:1027-131, Dec. 21, 2006.

These studies raise the exciting possibility that antimicrobial therapy might be implemented to alter the [gut] microbiome and tip the balance towards weight balance, or even weight loss, with no sacrifice in caloric intake.

Joe Heitman
Duke University Medical Center,
United States of America

W.E. Walden et al., "Structure of dual function iron regulatory protein 1 complexed with ferritin IRE-RNA," Science, 314:1903-8, Dec. 22, 2006.

The ability to adjust functionality between cytosolic aconitase and iron regulatory factor through the binding and release of an 4Fe-4S cluster is fascinating. The idea that the 4Fe-4S cluster is conceivably quite labile is very intriguing. It will be quite interesting to learn the mechanistic basis for addition/removal of the cluster.

Walter Chazin
Vanderbilt University,
United States of America

These papers were selected from multiple disciplines from the Faculty of 1000, a web-based literature awareness tool (www.f1000biology.com).