Papers to watch

K.M. Wassarman, R.M. Saecker, "Synthesis-mediated release of a small RNA inhibitor of RNA polymerase," Science, 314:1601-3, Dec. 3, 2006. "Besides confirming that the natural 6S RNA acts as a decoy by mimicry of the DNA promoter open complex, the authors show that inhibitory RNA can act as a transcriptional template, and that the inhibitory complex is destabilized by such transcription." Jim MaherMayo Clinic College of Medicine, United States

The Scientist Staff
Jan 31, 2007

K.M. Wassarman, R.M. Saecker, "Synthesis-mediated release of a small RNA inhibitor of RNA polymerase," Science, 314:1601-3, Dec. 3, 2006.

"Besides confirming that the natural 6S RNA acts as a decoy by mimicry of the DNA promoter open complex, the authors show that inhibitory RNA can act as a transcriptional template, and that the inhibitory complex is destabilized by such transcription."

Jim Maher
Mayo Clinic College of Medicine, United States


R. Redon et al., "Global variation in copy number in the human genome," Nature, 444:444-54, Nov. 23, 2006.

"This study uses both [genotype data and array-based hybridizations] in the analysis of 270 individuals, the largest number yet examined. Remarkably, the authors find that 12% of the genome is contained in copy number variants."

Jonathan Flint
University of Oxford, United Kingdom


J. Ule, et al., "An RNA map predicting Nova-dependent splicing regulation," Nature, 444:580-6, Nov. 30, 2006 .

"Depending...