The Scientist

Date: November 25, 1996


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Philippa Marrack
Howard Hughes Medical Institute, National Jewish Center, Denver

Throughout their scientific careers, Philippa Marrack and John Kappler, husband and wife immunology researchers, have focused their work on T cells. In recent years, their research has increased our knowledge of how T cells recognize antigens in association with major histocompatibility complex (MHC) proteins.

"The MHC proteins are the most polymorphic proteins that exist in humans. They control graft rejection and respond to infection and autoimmunity. They have a huge effect on human health and disease," notes Marrack.

Since their discovery of the T-cell receptors...

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