Physiology

After a long soak in the tub, fingers may emerge wrinkled. The real reason for this curious phenomenon lies under the skin, in the vasculature and nervous systems.

Suppressing a transcription factor induced energy burning in fat cells, offering therapeutic targets to treat obesity and metabolic diseases.

Alayna Loiselle has found a way to bring therapeutics straight to an injured tendon.

Changing body shapes and coordinated wiggling provide lift and stability for gravity-defying reptiles.

A neuropeptide helps starfish shed their arms to escape predators, providing clues about the mechanisms regulating self-amputation.

A brain-derived hormone that improves bone health could guide new treatments for age-related bone conditions. 

Explore how researchers use organoids to understand tissue regeneration and develop novel therapies.

Discover how spatial transcriptomics and proteomics advance wound healing research.

Urban myths cry turkey, but the science behind why Thanksgiving feasts induce sleep suggests otherwise.

Microfluidic chips that mimic the complex human cervical environment provide a platform to study the reproductive tract and associated infections like bacterial vaginosis.

Scientists identified the mechanoreceptor that triggers the distinctive shake-off behavior observed in mice when they become wet.

New 3D blueprints that highlight tumor complexity reveal several new discoveries, some of which challenge existing theories of cancer progression.

Discovered 30 years ago, microRNAs are increasingly recognized as important regulators of cell physiology and human disease.

Pressure wounds are a growing healthcare issue, and accurate characterization is necessary for appropriate treatment.

Human liver cells follow their own circadian rhythms, which regulate drug metabolism and infection.

Victor Ambros and Gary Ruvkun won this year’s Physiology or Medicine award for the discovery of microRNA and its role in post-transcriptional gene regulation.

A new study shows that a constellation of genetic changes link the timing of puberty to weight gain and other biological processes.

Python heart muscles ramp up their force to sustain metabolic activity to maintain increased metabolism during feeding.

Studying human embryonic development is complicated for several reasons. Models derived from pluripotent stem cells representing distinct stages offer a path to studying this process.