Edited by: James Kling
K.A. Dill, S. Bromberg, K.Z. Yue, K.M. Fiebig, D.P. Yee, P.D. Thomas, H.S. Chan, "Principles of protein-folding-a perspective from simple exact models," Protein Science, 4:561-602, 1995. (Cited in more than 140 papers through June 1997)

Comments by Ken A. Dill and Sarina Bromberg, University of California, San Francisco

Photo: Phil Mezcy

'ONE-STOP SHOPPING': Ken Dill’s review paper gives a "new, and perhaps controversial, perspective on protein folding."
The common metaphor of genes as blueprints for organisms fails in at least one respect: They specify only linear amino acid sequences, and not directly the structures and functions of the proteins they encode. The ability to predict structure through the amino acid sequence alone could assist drug development. "More broadly, an understanding of protein folding might teach us how to design other classes of polymeric materials to have the sophisticated functions that proteins have," says Ken...

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