Front Page | Science Seen; Models and Targets; Interdisciplinary Research
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MODELS AND TARGETS
Johns Hopkins School of Medicine researchers developed a murine model to investigate the role of the HIC1 gene, which encodes a zinc-finger transcription factor. HIC1 is hypermethylated (in cancer) and therefore transcriptionally silent in many cancer types. HIC1-/- mice were not viable. But, heterozygotes developed normally for about a year, and then a variety of sex-dependent tumors arose. Males displayed...