Brain Cells Transplant May Prove Useful as Stroke Treatment

About 4 million Americans are survivors of a stroke, the leading cause of adult disability, according to the American Heart Association. Historically, stroke medicine has focused on prevention, immediate treatment, and years of rehabilitation. Now, University of Pittsburgh Medical Center (UPMC) researchers have initiated clinical trials that may ultimately lead to restoration of affected abilities even years after stroke occurrence (D. Kondziolka et al., "Transplantation of cultured human neuronal cells for patients with stroke," Neurology, 55:565-569, Aug. 22, 2000). Following transplantation of laboratory-grown neuronal cells into a stroke patient's brain earlier this year, Douglas Kondziolka, UPMC professor of neurological surgery and radiation oncology, and co-researchers recently completed a 12-patient trial using the same type of cells, LBS-Neurons, supplied by study sponsor Layton BioScience, Inc. of Atherton, Calif. The patients, whose strokes occurred six months to six years previously, had...

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