-GalCer

-galactosylceramide can boost vaccine induced cellular immunity.

Tudor Toma(t.toma@ic.ac.uk)
Mar 7, 2002

Parasitic and viral infections can be prevented by vaccine induced cellular immunity, but molecules that can enhance the effects of the vaccines are still largely unknown. In March 4 online Journal of Experimental Medicine, Gloria Gonzalez-Aseguinolaza and colleagues from New York University School of Medicine, show that natural killer T cell glycolipid ligand α-galactosylceramide (α-GalCer) can enhance the protective immunity induced by malaria vaccines.

Gonzalez-Aseguinolaza et al. used mice and found that simultaneous administration of α-GalCer with doses of irradiated sporozoites or recombinant viruses expressing a malaria antigen greatly enhanced the level of protective anti-malaria immunity. The α-GalCer improved antigen-specific CD8+ T cell responses, and to a lesser degree, Th1-type responses and required the co-administration ofCD1d molecules, Vα14 NKT cells and interferon γ (J Exp Med 2002, 195:617-624).

"These findings should contribute to the design of more effective vaccines against malaria and other intracellular...

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