A dictionary for genomes
With sequence information in hand, the search for regulatory sites in promoters can be done by computers rather than cloning. But the primary tools for analysis, multiple-alignment algorithms, can only handle a small amount of sequence data. In the August 29 Proceedings of the National Academy of Sciences, Bussemaker et al. introduce an alternative algorithm that they dub 'MobyDick' (Proc Nat Acad Sci USA 2000, 97: 10096-10100). MobyDick treats DNA sequence as text in which allthewordshavebeenru
Aug 30, 2000
With sequence information in hand, the search for regulatory sites in promoters can be done by computers rather than cloning. But the primary tools for analysis, multiple-alignment algorithms, can only handle a small amount of sequence data. In the August 29