The secreted WNT proteins activate two distinct signaling pathways: the canonical WNT/β-catenin pathway and a WNT/Ca2+ pathway that interferes with the canonical pathway. In the May 16
Members of the NF-AT (nuclear factor of activated T cells) family play a pivotal role in the regulation of gene expression in T lymphocytes. NF-AT is translocated to the nucleus following activation by calcineurin in response to Ca2+ signaling. Saneyoshi
They found that XNF-AT showed Ca-dependent dephosphorylation during development, and that dephosphorylation lead to nuclear localization and transcriptional activation. Injection of an activated XNF-AT mutant lead to 'ventralized'