An emerging pattern
Three studies shed new light on how members of the bone morphogenetic protein family are regulated during embryonic development.
During development, organizing centres at key locations in the embryo secrete morphogens that become distributed in a concentration gradient. It is thought that cells along the gradient adopt different fates depending on the concentration of the morphogen they encounter. In the 22 March
All three studies focus on the role of the Twisted gastrulation (Tsg) protein and find that, in both vertebrates and invertebrates, this protein binds to members of the BMP family, preventing them from signalling. The authors — Jeffrey Ross of the University of Minnesota and co-workers, Ian Scott of the University of Wisconsin Medical School and co-workers, and Chenbei Chang of Rockefeller University and colleagues — studied Tsg function in
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