Arrays for replication
DNA microarrays are normally used to detect variation in mRNA abundance. But in the August 15 Proceedings of the National Academy of Sciences Khodursky et al. use the arrays to track the progress of replication forks in Escherichia coli (Proc Natl Acad Sci USA 2000, 97:9419-9424). In a bacterial culture that is replicating synchronously, genomic DNA from replicated regions gives a stronger array signal than unreplicated DNA. Khodursky et al. use this signal variation to show that normal replicat
Aug 20, 2000
DNA microarrays are normally used to detect variation in mRNA abundance. But in the August 15