Arsenic and old telomerase
Although arsenic is effective in the treatment of acute promyelocytic leukemia it also has carcinogenic side effects, but the exact carcinogenic mechanisms remain unclear. In November Journal of Clinical Investigation Wen-Chien Chou and colleagues from Johns Hopkins University School of Medicine, Baltimore, US show that at clinically relevant doses arsenic inhibits the transcription of the reverse transcriptase subunit of the human telomerase gene (hTERT).Chou et al. found that exposing NB4 leuk
Nov 25, 2001
Although arsenic is effective in the treatment of acute promyelocytic leukemia it also has carcinogenic side effects, but the exact carcinogenic mechanisms remain unclear. In November
Chou
"These results may explain the seemingly paradoxical carcinogenic and antitumor effects of arsenic", concluded Chou.