Caretakers and gatekeepers
Cellular gatekeepers include the proteins that regulate cell cycle progression in response to DNA damage, and the DNA repair pathways function as genomic caretakers. The p53 and ATM (ataxia-telangiectasia-mutated) proteins behave as cellular gatekeepers, whereas the non-homologous end-joining (NHEJ) DNA repair machinery acts as a genomic caretaker. NHEJ factors include Ku70, Ku80 and the DNA-PK enzyme, plus XXRC4 and DNA Ligase IV (Lig4), which function in ligation.In 6 March Proceedings of the
Mar 13, 2001
Cellular gatekeepers include the proteins that regulate cell cycle progression in response to DNA damage, and the DNA repair pathways function as genomic caretakers. The p53 and ATM (ataxia-telangiectasia-mutated) proteins behave as cellular gatekeepers, whereas the non-homologous end-joining (NHEJ) DNA repair machinery acts as a genomic caretaker. NHEJ factors include Ku70, Ku80 and the DNA-PK enzyme, plus XXRC4 and DNA Ligase IV (Lig4), which function in ligation.
In 6 March