CDC screen
Classic screens for genes that regulate the cell division cycle (CDC genes) in yeast have searched for temperature-sensitive mutants with a loss-of-function phenotype. In the March 27 Proceedings of the National Academy of Sciences, Stevenson et al describe an alternative approach to identifying novel CDC genes (Proc Natl Acad Sci USA 2001, 98:3946-3951). They screened for genes whose overexpression affects cell-cycle progression. They used a Saccharomyces cerevisiae expression library under the
Mar 27, 2001
Classic screens for genes that regulate the cell division cycle (