Chemotactic blockbuster
Dictyostelium discoideum cells display a strong chemotactic response to cyclic adenosine 3',5'-monophosphate (cAMP), mediated by a cell surface receptor and G protein-linked signaling pathway. In October 26 Science, Masahiro Ueda and colleagues from Osaka University, Japan, show the first real-time images of how single fluorescent-labeled cAMP molecules bind to their receptors on living Dictyostelium amoebae.Ueda et al. used an objective-type total internal reflection fluorescence microscope to
Oct 30, 2001
Ueda
"People know that receptors bind and release molecules, but until now no one has seen...