Damage in worms
Combined functional genomics approaches help to identify novel genes involved in the DNA damage response pathway in nematodes.
The DNA damage response (DDR) is essential for normal cell function and for tumour suppression. In January 4
They combined functional genomics approaches — that is protein-protein interaction mapping and high-throughput phenotype analysis — to investigate DDR in
The team confirmed interactions observed in other species and found new interacting partners. Proteome-wide interaction screening identified a large number of 'interologs', enabling Boulton
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