defect in Huntington's disease
In Huntington's disease mutant huntingtin protein has a direct effect on mitochondria, causing calcium handling defects.
Jul 1, 2002
Huntington's disease (HD) is neurodegenerative illness caused by CAG triplet repeats in the gene encoding huntingtin protein (Htt), but the precise molecular mechanisms involved in the pathogenesis of the disease have remained unclear. In 1 July advanced online
Panov
In addition, they identified mutant huntingtin on neuronal mitochondrial membranes, and using a fusion protein containing an abnormally long polyglutamine...