Defective axonal transport in Alzheimer's disease
The normal function of amyloid precursor protein, involved in Alzheimer's disease, is to transport cellular materials along the axons.
Dec 10, 2001
Alzheimer's dementia is caused by accumulation of amyloid-β protein in neurons, formed from proteolytisis of amyloid precursor protein (APP), but the normal role of APP in the brain remains unclear. In December 6,
Kamal
A previous study, from the same laboratory, demonstrated that proteolytic processing of APP generates a carboxy-terminal fragment of APP, which carries a...