Deficient domain protein reveal pathway for cardiomyopathy
associated LIM gene destabilizes actin anchorage sites in cardiac muscle.
Apr 30, 2001
Cytoskeletal mutations have been implicated in the genetically based forms of dilated cardiomyopathy, but the mechanisms by which heart failure develops is not known. In May
Pashmforoush
These results implicate α-actinin–associated proteins in the onset of heart disease and provide a possible pathway that links gene defects with cardiomyopathy.