Destruction before salvation
Mouse models of cancer are primarily soft tissue sarcomas and lymphomas, whereas 90% of human cancers are epithelial in origin. In the August 10 Nature, Artandi et al. suggest that the difference arises from higher levels of telomerase (the enzyme that adds a protective cap on the end of chromosomes) in mice (Nature 2000, 406:641-645). When the researchers combine a mouse telomerase knockout with a mutation in the tumor suppressor p53, non-reciprocal translocations appear, followed by epithelial
Aug 14, 2000
Mouse models of cancer are primarily soft tissue sarcomas and lymphomas, whereas 90% of human cancers are epithelial in origin. In the August 10
Interested in reading more?
Become a Member of
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member?