dsRNA can turn off genes
RNA interference (RNAi) is an elegant technique in which double-stranded RNA (dsRNA) can direct the degradation of homologous RNA species leading to post-transcriptional gene silencing. In the October 2 EMBO Journal Mette et al. extend dsRNA applications by showing that dsRNA corresponding to sequences from the nopaline synthase promoter (NOSpro) could disrupt transcriptional activation (EMBO Journal 2000, 19:5194-5201). The dsRNA trans-silencing was accompanied by induced methylation of the tar
Oct 22, 2000
RNA interference (RNAi) is an elegant technique in which double-stranded RNA (dsRNA) can direct the degradation of homologous RNA species leading to post-transcriptional gene silencing. In the October 2