Editing the immune system
B lymphocytes that produce antibodies recognizing self antigens are tolerized by a process of clonal selection, which involves clonal deletion, anergy and a gene-recombination event called receptor editing. In the February 23 Science, Casellas et al. describe a model mouse system for investigating the importance of receptor editing (Science 2001, 291:1541-1544). They generated a polymorphic immunoglobulin kappa allele by replacing the mouse kappa constant (mCkappa) region with the human sequenc
Feb 22, 2001
B lymphocytes that produce antibodies recognizing self antigens are tolerized by a process of clonal selection, which involves clonal deletion, anergy and a gene-recombination event called receptor editing. In the February 23