Events at the ends

Telomere position effects in human cells may account for gene expression changes as cells grow older.

Jonathan Weitzman(jonathanweitzman@hotmail.com)
Jun 14, 2001

The telomere position effect (TPE), first described in yeast, causes the reversible silencing of genes near telomeres by a mechanism that depends on telomere length and the distance to the gene. Evidence for TPE in human cells might explain the altered cellular phenotypes associated with replicative aging and telomere shortening. In the June 15 Science, Baur et al. report the first demonstration of TPE in human cells (Science 2001, 292:2075-2077). They created new telomere structures in HeLa cells by introducing a plasmid containing a luciferase reporter gene next to a stretch of telomeric repeats. Cell clones with a telomeric reporter expressed ten times less luciferase than clones with a random internal integration site. The telomere silencing effects could be overcome by treating cells with an inhibitor of histone deacetylase (Trichostatin A). Baur et al. found that when they elongated the telomere length, using the catalytic subunit...

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