Fibroblast clocks
Mammalian circadian clocks are regulated by a series of interacting positive and negative transcription-translation feedback loops in the hypothalamic suprachiasmatic nucleus (SCN). In the April 13 Science, Yagita et al. describe an in vitro model system that resembles the molecular oscillator in the SCN (Science 2001, 292:278-281). Cultured fibroblasts exhibit cycling circadian gene expression when stimulated with the vasocontracting peptide endothelin-1. Endothelin-1 induced cycling phases of
Apr 17, 2001
Mammalian circadian clocks are regulated by a series of interacting positive and negative transcription-translation feedback loops in the hypothalamic suprachiasmatic nucleus (SCN). In the April 13