T cells seek and destroy cells containing viruses. They identify infected cells by the recognition of specialised proteins such as MHC class I molecules that display virus-derived proteins on the cell surface. But viruses like cytomegalovirus (CMV) disrupt the production of MHC class I molecules, thereby evading the T cell-mediated immune response. In March
In addition to MHC class I molecules CD8+ T cells also express the receptor NKG2D that binds to the protein MIC. Working on cultured fibroblast and endothelial cells, Groh