FOXO transcription factor stimulates repair
The protein kinase Akt promotes cell survival by phosphorylating and inhibiting FOXO forkhead transcription factors. FOXO factors have been linked to stress responses and the regulation of longevity. In the April 19 Science, Hien Tran and colleagues at Boston's Children's Hospital define a role for the FOXO3a family member in the response to DNA damage (Science 2002, 296:530-534).Tran et al. created a Rat-1 fibroblast cell line expressing a tamoxifen-inducible FOXO3a protein. FOXO3a expression r
Apr 21, 2002
The protein kinase Akt promotes cell survival by phosphorylating and inhibiting FOXO forkhead transcription factors. FOXO factors have been linked to stress responses and the regulation of longevity. In the April 19
Tran
They reported that FOXO3a directly regulates transcription of the