Gene therapy with histones
In the October 10 Proceedings of the National Academy of Sciences, Balicki et al. report that histone H2A can be used to increase the efficacy of gene therapy (Proc Natl Acad Sci USA 2000, 97:11500-11504). Histone H2A has been used in the past to coat DNA prior to transfection. It appears to work both because of its positive charge and some other property, which is presumed to be its nuclear-localizing activity. Balicki et al. use H2A for in vitro delivery of the gene for interleukin-2 (IL-2) to
Oct 12, 2000
In the October 10