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Genes modulated by Ginkgo biloba revealed by DNA microarrays

Millions of people take herbal remedies for conditions such as the common cold and Alzheimer's. A new approach may help to elucidate the mechanisms by which these compounds work in the body.

Dan Ferber(ferber@nasw.org)

URBANA, ILLINOIS Millions of people take herbal remedies for conditions ranging from mild problems such as the common cold to severe disorders, such as Alzheimer's disease. But even when these types of medicines have proved effective in clinical trials, it often remains unclear as to how they work in the body. Researchers typically test a hypothesis that is essentially an educated guess as to how, for example, a herbal medicine such as Echinacea might potentially boost the immune system. But, a new approach could help speed such research by removing a lot of the guesswork.

Pete Schultz of The Scripps Research Institute in La Jolla, California, and his colleagues have used DNA microarrays to see how a Ginkgo biloba extract affects brain function on the molecular level (Proc Natl Acad Sci USA 2001, 98:6577-6580.). Although thousands of consumers buy Ginkgo biloba off the shelf to ease symptoms of...

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