Glutamate fuels brain tumor growth
Glutamate is one of the principal neurotransmitters in the brain, but in excess can be highly neurotoxic. In September Nature Medicine Takahiro Takano and colleagues from the New York Medical College, Valhalla, New York, show that in addition to being neurotoxic, glutamate release from glioma cells also promotes growth of malignant gliomas.Takano et al. used bioluminescence to detect glutamate release from freshly prepared brain slices. They found that implanted glioma cells continue to secrete
Sep 3, 2001
Glutamate is one of the principal neurotransmitters in the brain, but in excess can be highly neurotoxic. In September
Takano
These findings suggest a new approach for the treatment of brain tumors, based on antagonizing...