Haematopoietic cell gene therapy with foamy viruses
Transfer of therapeutic genes into haematopoietic stem cells can potentially cure blood disorders such as X-linked severe combined immunodeficiency. But human stem cells are relatively intractable to the available viral vectors. In August Blood, George Vassilopoulos and colleagues from University of Washington, Seattle, describe a new vector system based on foamy viruses from the spumavirus family that can be used for gene transfer into murine haematopoietic stem cells.Foamy viruses are nonpatho
Jul 25, 2001
Transfer of therapeutic genes into haematopoietic stem cells can potentially cure blood disorders such as X-linked severe combined immunodeficiency. But human stem cells are relatively intractable to the available viral vectors. In August
Foamy viruses are nonpathogenic retroviruses with a wide tissue tropism that are commonly found in mammalian species. Vassilopoulos
Vassilopoulos