Hammering melanoma
Survivin is an inhibitor of apoptosis that is involved in tissue development and early reports have suggested that it may have a role in the survival of cancer cells. In January 15 Journal of Clinical Investigation, Marzia Pennati and colleagues from Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy show that ribozyme-mediated attenuation of survivin expression increased the susceptibility of melanoma cells to cisplatin-induced apoptosis.Pennati et al. developed a strategy for
Jan 27, 2002
Survivin is an inhibitor of apoptosis that is involved in tissue development and early reports have suggested that it may have a role in the survival of cancer cells. In January 15
Pennati
These results "extend and corroborate earlier evidence indicating that attenuating survivin expression renders these [melanoma] cells more susceptible to cisplatin-induced apoptosis. These...