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Homocysteine levels as a measure of myocardial damage

A recent study shows that homocysteine levels reflect the extent of myocardial damage in acute ischemia.

The Scientist Staff

Plasma homocysteine levels are positively correlated with the extent of ischemic myocardial damage in patients presenting with acute coronary syndromes (ACS), a multicenter research team report in Journal of the American College of Cardiology.

Al-Obaidi and colleagues studied 390 consecutive patients who presented with acute myocardial infarction (MI) or unstable angina pectoris (UA). Analysis of clinical and biochemical parameters revealed that there was a significant increase in peak cardiac troponin T (cTnT) levels in the highest homocysteine quintile (7.85 μg/l, p<0.0001 for top versus bottom quintile). The authors also report a step-up in peak cTnT levels in the top homocysteine quintile, although this was restricted to UA patients (p<0.0001 for analysis of variance, p<0.0001 for top versus bottom quintile). Multivariate regression analysis showed that cTnT levels were influenced by greater age, thrombolysis and a final diagnosis of MI, as well as by homocysteine levels in...

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