Horizontal transfer of tumorigenesis
Apoptotic bodies are rapidly cleared in the body by phagocytosis. In the May 22 Proceedings of the National Academy of Sciences, Bergsmedh et al. provide evidence that the uptake of apoptotic bodies can deliver oncogenes to the phagocytotic host cell (Proc Natl Acad Sci USA 2001, 98:6407-6411). They could detect the horizontal transfer of H-rasV12 or c-myc oncogenes from dying, transformed rat fibroblast cells to recipient mouse fibroblasts. DNA transfer was detected by PCR analysis and fluoresc
May 16, 2001
Apoptotic bodies are rapidly cleared in the body by phagocytosis. In the May 22