The largest twin study on epigenetic profiles yet reveals the extent to which lifestyle and age can impact gene expression, an international research team reports in this week's
"These findings help show how environmental factors can change one's gene expression and susceptibility to disease, by affecting epigenetics," Esteller told
Esteller and colleagues in Sweden, Denmark, Spain, England, and the United States studied 80 sets of identical twins, ranging in age from 3 to 74 years. Their aim was to explore what role epigenetics plays in generating phenotypic differences between genetically identical twins.
The researchers analyzed the twins' global DNA methylation and histone H3 and H4 acetylation in samples from lymphocytes, buccal mucosal epithelial cells, skeletal muscle...