How tumor cells spread
Colon cancer cell migration is driven by the interaction of APC and Asef.
Feb 23, 2003
The adenomatous polyposis coli tumor suppressor (APC) is a large multidomain protein that plays an integral role in intercellular adhesion and in the Wnt/Wingless signaling transduction pathway — key in a number of developmental processes and in tumorigenesis.
Kawasaki et al. overexpressed several forms of Asef in epithelial cells, and observed that cell-cell adhesion decreased and MDCK cell motility was stimulated. In addition a truncated form of...