HP1 dynamics
Fluorescent HP1 proteins demonstrate the dynamic nature of mammalian heterochromatin.
Jan 30, 2003
Gene silencing can be achieved by packaging of genes into repressive heterochromatin domains. In the January 31
Richard Festenstein and colleagues generated transgenic mice that express a chimeric protein of HP1β fused to green fluorescent protein (GFP) in T lymphocytes (
In the second paper Thierry Cheutin and colleagues describe a similar approach using GFP fusions of HP1α, -β and -γ in CHO cells (