A broad-ranging international collaboration reports today (April 20) in
The Japan-based collaboration also reveals a novel tool for making sense of the human genome. The H-Invitational Database (H-InvDB), based on more than 41,000 full-length cDNAs, comprises the most elaborate annotation of human genes to date. It includes descriptions of gene structures, novel alternative splicing isoforms, functional domains, subcellular localizations, metabolic pathways, and comparisons with mouse cDNA. The database is free and open to all.
“This is a pretty important contribution,” Sean Eddy, who heads the Howard Hughes Medical Institute genetics lab at Washington University in St. Louis, told