Impotent B cells
In chronic lymphocytic leukaemia the non-malignant B cells do not mature to produce IgG and IgA because of an interaction with CD30+ T cells.In patients with chronic lymphocytic leukaemia antibody production by B cells is severely impaired and this is associated with increased susceptibility to bacterial infections. The mechanisms behind the immune defects have remained elusive. In the February issue of Nature Immunology, researchers from Cornell University, New York, show how leukaemia cells in
Jan 29, 2001
In chronic lymphocytic leukaemia the non-malignant B cells do not mature to produce IgG and IgA because of an interaction with CD30+ T cells.
In patients with chronic lymphocytic leukaemia antibody production by B cells is severely impaired and this is associated with increased susceptibility to bacterial infections. The mechanisms behind the immune defects have remained elusive. In the February issue of
T cells express a key molecule (CD30) in the presence of leukaemic cells. Using
It may therefore be possible to use this research to develop a...