In chronic lymphocytic leukaemia the non-malignant B cells do not mature to produce IgG and IgA because of an interaction with CD30+ T cells.
In patients with chronic lymphocytic leukaemia antibody production by B cells is severely impaired and this is associated with increased susceptibility to bacterial infections. The mechanisms behind the immune defects have remained elusive. In the February issue of
T cells express a key molecule (CD30) in the presence of leukaemic cells. Using
It may therefore be possible to use this research to develop a...