In control of body size
The proto-oncogene c-Myc has been implicated in the genesis of many different types of tumors, but its role in normal physiology remains unclear. In December 13 Nature, Andreas Trumpp and colleagues from University of California at San Francisco show that in mammals c-Myc controls the decision to divide or not to divide and thereby functions as a crucial mediator of signals that determine organ and body size.Trumpp et al. generated an allelic series of mice in which c-Myc expression was incremen
Dec 13, 2001
The proto-oncogene c-Myc has been implicated in the genesis of many different types of tumors, but its role in normal physiology remains unclear. In December 13
Trumpp
This suggests that c-Myc mediated responses controls mammalian body size and that these mechanisms...