Indirectly regulating nitric oxide
The structure of the enzyme DDAH that controls levels of arginine derivates offers the basis for designing selective indirect inhibitors of NO.
Jul 26, 2001
Nitric oxide (NO) is a signalling molecule involved in a range of diseases and conditions, such as asthma, cancer and impotence. The natural levels of arginine derivates — which can inhibit nitric oxide synthase and decrease NO — are controlled in part by dimethylarginine dimethylaminohydrolase (DDAH). In August
Murray-Rust