Insects may have complex immunity

Thanks to alternate splicing of Dscam, they could possess up to 18,000 immune receptors

Charles Choi(cqchoi@nasw.org)
Aug 18, 2005

Insects may possess a hitherto unsuspected molecular complexity in their immune system, comparable to the antibody system of mammals, scientists report online this week in Science.

"The number of immune receptors might go from a couple of dozen up to thousands in insects. The complexity there might have really been underestimated," senior author Dietmar Schmucker, of Harvard Medical School in Boston, told The Scientist.

In 2000, Schmucker and colleagues discovered that the Down syndrome cell adhesion molecule gene (Dscam) could, through alternative splicing, generate more than 38,000 proteins in Drosophila. The immunoglobulin super family receptor appeared to guide neuronal wiring.

In the current study, the researchers investigated whether Dscam played a role in immune response. Using reverse transcriptase polymerase chain reaction (RT-PCR), they found Dscam expression in Drosophila fat body cells, which secrete antimicrobial peptides, and hemocytes, which are involved in phagocytosis. Using...

Interested in reading more?

Become a Member of

Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member?