Insights into paracetamol poisoning
Glutathione S-transferases (GST) may provide a means for treating fatal liver damage caused by paracetamol overdose. In a paper published in 7 November Proceedings of the National Academy of Sciences, Henderson et al provide a new insight into how the enzyme GST Pi may moderate the toxic effects of paracetamol (acetaminophen).When overdoses of paracetamol are taken, too much of the compound N-acetyl-p-benzoquinoneimine (NAPQI) is produced; it covalently binds to proteins and other macromolecules
Nov 7, 2000
Glutathione
When overdoses of paracetamol are taken, too much of the compound
Henderson