Intracellular localization gives first clue to protein function
Going from gene sequence to protein function presents a great challenge to genome biology. In the September 15 EMBO Reports, Simpson et al. suggest that the systematic identification of subcellular localization can significantly enhance our ability to assign functions to unknown ORFs (EMBO Reports 2000, 1:287-292). Simpson et al. outline a strategy for such an approach. They adapted the Gateway cloning system to allow rapid, directional cloning of ORFs by recombination, and generate amino- and c
Oct 5, 2000
Going from gene sequence to protein function presents a great challenge to genome biology. In the September 15