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knockouts and Rett syndrome

Mice lacking the transcriptional repressor Mecp2 have symptoms resembling the neurological disorder Rett syndrome.

Kenneth Lee(kenlee_fr@yahoo.fr)

Rett syndrome, an inherited neurological disorder, is one of the most common causes of mental retardation in females. Babies with Rett syndrome develop normally until 6–18 months, at which point they show a reduction in brain size and become prone to seizures and autism. The syndrome is caused by a mutation in the MECP2 gene, which maps to the X chromosome. Females with one intact copy of the gene survive until adulthood, despite the neurological symptoms. Male embryos that carry the mutation die during development. The MECP2 gene encodes the methyl-CpG-binding protein 2, which binds to methylated sites in the genome and represses transcription of adjacent genes.

Two groups, one led by Adrian Bird of the University of Edinburgh, and the other by Rudolf Jaenisch of the Whitehead Institute for Biomedical Research, Massachusetts, report in March Nature Genetics that mice having mutations in the Mecp2 gene — the...

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