Lactose intolerance DNA

A DNA variant upstream of the lactase-phlorizin hydrolase gene is associated with lactose intolerance.

Tudor Toma(t.toma@ic.ac.uk)
Jan 14, 2002

Lactose intolerance (lactase non-persistence) is the inability to digest the sugar (lactose) present in dairy products and is caused by a decline in the epithelial production of lactase-phlorizin hydrolase (LPH) in the small intestine. No DNA variation correlating to this lactase non-persistence exists for this enzyme, but in January 14 online Nature Genetics, Nabil Sabri Enattah and colleagues from University of Helsinki, Finland, show that a DNA variant exists upstream of the LCT gene encoding LPH that does associate with the disorder.

Enattah et al. performed a sequence analysis and found a DNA variant, C/T–13910, on 2q21 that completely associates with lactose intolerance in Finnish families and a sample set of 236 individuals from four different populations. They also found a second variant, G/A–22018, 8 kb telomeric to C/T–13910, which is also associated with the trait in 229 of 236 cases (...