In the 10 years since the discovery of the hormone leptin and its appetite-suppressing activity in mice, the hormone has provided a good deal of insight into how a metabolic signal can affect the central nervous system. In the April 2
Both teams used leptin-deficient mice (
“These findings are important for the study of leptin and its potential therapeutic value in the treatment of obesity and related disorders like diabetes,” said Jenni Harvey, Wellcome Trust Research Fellow from University of Dundee, who was not involved in the studies.
“We were working on the POMC and NPY system,” said Tamas Horvath, associate professor...