Life after ESTs
Expressed sequence tags (ESTs) have given researchers a quick if dirty look at the coding potential of the human genome. But now in the November Nature Genetics, Penn et al. use microarray experiments to conclude that the human genome project will uncover many genes not previously discovered by EST sequencing (Nat Genet 2000, 26:315-318). They scan 350 Mb of finished and draft human sequence using three different gene-finding algorithms. Open reading frames (ORFs) predicted by at least two of th
Nov 6, 2000
Expressed sequence tags (ESTs) have given researchers a quick if dirty look at the coding potential of the human genome. But now in the November