Lipoprotein that promotes chronic TB infection
Mycobacterium tuberculosis (MTB) infection induces a strong immune response, but by an as yet unknown mechanism, can persist within macrophages. In July Journal of Immunology Erika Noss and colleagues from Case Western Reserve University, Cleveland, Ohio show that a 19-kDa lipoprotein produced by MTB, inhibits antigen processing by macrophages and prevents recognition by T cells, thereby promoting chronic TB infection.Using electroelution techniques, Noss et al. extracted a specific component fr
Jul 24, 2001
Using electroelution techniques, Noss
These results suggest...